viernes, 28 de mayo de 2010

Equine Surgery. Third Edition. 2006. AUER, Jörg A. et al.

Idioma: Inglés
Formato: PDF
Total de páginas: 1455
Tamaño: 50 MB


Since the publication of the first edition in 1992, Equine
Surgery has been accepted as a definitive clinical reference
and teaching text. Like the first two editions, the third
edition of the book has been prepared as a foundation text
for the art and science of modern equine surgery. Our intent
was to produce a comprehensive textbook that would be of
practical help to general practitioners, as well as provide
specialists and surgeons in training with a single reference
source on equine surgery. Accordingly, this third edition of
the book has been significantly enlarged and includes new
information, new authors, additional illustrations, and
many more line drawings and tables.
The task of reviewing the ever expanding literature into
concise chapters was considerable. As the editors, we divided
the responsibility for organizing the sections and inviting
authors between the two of us; and, we believe that the
outcome is consistency of content and presentation in the
final text. Additionally, we deliberately avoided omitting
well-known material and concentrating only on state of the
art techniques and procedures. We felt it was important that
students, practitioners, and clinicians have a comprehensive
textbook, discussing all aspects of this exciting field indepth,
while staying current with new developments.
All chapters in the third edition have been completely
revised and updated. Many new chapters were added in
areas of this discipline that are rapidly expanding. While
many authors remained the same, many new authors have
been added to this text, and we are indebted to all contributing
authors who helped us produce this book in a
timely fashion. We especially would like to thank David
Freeman, Anton Fürst, Susan Holcombe, Pete Knox, Wayne
McIlwraith and Rolfe M. Radcliff who provided a critical
review of the second edition, making suggestions for revision
and improvement of the third edition of this text. We
are also indebted to the staff of Elsevier, including Elizabeth
Fathman, Jolynn Gower (our most pleasant and constant
contact), John Dedeke, and especially John Casey (for his
tireless quest to keep the project on time and the editors
happy). Personal thanks to our administrative assistants,
Monika Gutscher (Zurich) and Martha Devlin (East
Lansing), without whom our lives would have been much
more complicated during the compilation of this book. A
special thank you goes to Mathias Haab of Zurich,
Switzerland, who did an excellent job in preparing all new
art work and in a most efficient manner. Finally, our most
sincere thanks to all the specialists who contributed to this
textbook, but most especially to the Diplomates in the
American and European Colleges of Veterinary Surgery for
their outstanding educational contributions.

Jörg Auer and John Stick, Editors

CONTENIDO

SECTION I SURGICAL BIOLOGY

-Shock: Pathophysiology, Diagnosis, and Treatment
-Sepsis and Endotoxemia
-Fluids, Electrolytes, and Acid–Base Therapy
-Hemostasis, Surgical Bleeding, and Transfusion
-Wound Repair-Metabolism and Nutritional Support of the Surgical Patient
-Surgical Site Infection and the Use of Antimicrobials
-Physiologic Response to Trauma: Evaluating the Trauma Patient
-Biomaterials, Surgical Implants, and Instruments


SECTION II SURGICAL METHODS

-Sterilization and Antiseptics
-Preparation of the Surgical Patient, the Surgery Facility, and the Operating Team
-Surgical Instruments
-Surgical Techniques
-Minimally Invasive Surgical Techniques
-Cryosurgery
-Lasers in Veterinary Surgery
-Suture Materials and Patterns
-Drains, Bandages, and External Coaptation



SECTION III RECENT ADVANCES IN ANESTHESIA

-Advances in Inhalation Anesthesia
-Modern Injection Anesthesia for Horses
-Anesthesia and Analgesia for Foals
-Recovery from Anesthesia
-Equine Pain Management


SECTION IV INTEGUMENTARY SYSTEM

-Principles of Reconstructive and Plastic Surgery
-Skin Grafting
-Management of Superficial Wounds
-Management of Deep and Chronic Wounds
-Management of Sinus Tracts and Fistulas
-Skin Conditions Amenable to Surgery


SECTION V ALIMENTARY SYSTEM

-Oral Cavity and Salivary Glands
-Esophagus
-Stomach and Spleen
-Colic: Diagnosis, Preoperative Management, and Surgical Approaches
-Principles of Intestinal Injury and Determination of Intestinal Viability
-Small Intestine
-Large Intestine
-Rectum and Anus
-Abdominal Hernias
-Postoperative Care and Complications Associated with Abdominal Surgery


SECTION VI RESPIRATORY SYSTEM

-Overview of Upper Airway Function
-Diagnostic Techniques in Equine Upper Respiratory Tract Disease
-Nasal Passages and Paranasal Sinuses
-Pharynx
-Larynx
-Guttural Pouch
-Trachea
-Thoracic Disorders
-Pleuropneumonia


SECTION VII NERVOUS SYSTEM

-Anatomy and Physiology of the Nervous System
-Diagnostic Procedures
-Developmental Vertebral Anomalies
-Surgical Treatment of Developmental Diseases of the Spinal Column
-Traumatic Disorders of the Spinal Column
-Peripheral Nerve Injury


SECTION VIII EYE AND ADNEXA

-Principles of Ophthalmic Surgery
-Eyelids
-Conjunctiva
-Third Eyelid
-Nasolacrimal System
-Cornea and Sclera
-Intraocular Surgery
-Surgical Management of Equine Recurrent Uveitis
-Orbit
-Ocular Emergencies and Trauma


SECTION IX REPRODUCTIVE SYSTEM

-Testis
-Penis and Prepuce
-Vulva, Vestibule, Vagina, and Cervix
-Ovaries and Uterus

SECTION X URINARY SYSTEM

-Principles of Urinary Tract Surgery
-Kidneys and Ureters
-Bladder
-Urethra

SECTION XI SELECTED TOPICS OF THE LAMENESS EXAMINATION

-Gait Analysis
-Diagnostic Anesthesia
-Diagnostic Medical Imaging
-Magnetic Resonance Imaging of the Equine Distal Limb
-Saddle Evaluation: Poor Fit Contributing to Back Problems in Horses



SECTION XII MUSCULOSKELETAL SYSTEM

-Emergency Treatment and Transportation of Equine Fracture Patients
-Molecular Biology Techniques in Musculoskeletal Research
-Bone Biology and Fracture Healing
-Principles of Fracture Treatment
-Bone Grafts and Bone Replacements
-Synovial Joint Biology and Pathobiology
-Principles of Treatment of Joint Disease
-Arthrodesis Techniques
-Diagnosis and Management of Tendon and Ligament Disorders
-Biology and Management of Muscle Disorders and Diseases
-Synovial and Osseous Infections
-Angular Limb Deformities
-Flexural Limb Deformities
-Osteochondrosis
-Subchondral Cystic Lesions
-Foot
-Phalanges and the Metacarpophalangeal and
Metatarsophalangeal Joints
-Metacarpal and Metatarsal Bones
-Carpus
-Radius and Ulna
-Shoulder
-Tarsus
-Tibia
-Stifle
-Femur and Pelvis
-Craniomaxillofacial Disorders

INDEX


miércoles, 19 de mayo de 2010

IMMUNOPHARMACOLOGY, KHAN, M. Manzoor. 2008.




Versión: PDF
Idioma: Inglés
Total de páginas: 275
Tamaño: 5,75 MB

CONTENIDO


1 Overview of the Immune Response
Introduction
-Innate Immunity
-Physical Barriers
-Chemical Barriers
-Cellular Barriers
-Innate Mechanisms
-Adaptive/Acquired Immune Response
-Immunogens and Antigens
-Antibodies
-Classes of Immunoglobulins
-Cell Cooperation in Antibody Response
-Primary and Secondary Antibody Responses
-Cells Involved in the Immune Response
-Lymphoid Cells
-Antigen-Presenting Cells
-Polymorphonuclear Leukocytes
-CellularMigration
-Cell Adhesion Molecules
-Integrins
-Selectins
-Immunoglobulin Superfamily
-Cadherins
-Molecules That Recognize Antigen
-T-Cell Receptor
-T-Cell Activation, T-Cell Receptor Complex and Signal Transduction
-Pre-T-Cell Receptor
-Antigen Recognition
-Antigen–Antibody Binding
-The Structure of Antigens
-T-Cell Antigen Recognition
-Major Histocompatibility Complex
-Major Histocompatibility Complex Molecules



2 Role of Cytokines


Introduction
-Interleukin-1
-Kineret(Anakinra)
-Interleukin-2
-Interleukin-2 Receptors
-Clinical Uses of Interleukin-2
-Interleukin-4
-Interleukin-5
-Interleukin-6
-Interleukin-9
-Interleukin-10
-Interleukin-11
-Oprelvekin (Neumega)
-Interleukin-13
-Interleukin-18
-Interferons
-Type I Interferons
-Clinical Applications of Interferons
-Type II Interferons
-Colony-Stimulating Factors
-Clinical Uses of Colony-Stimulating Factors
-Tumor Necrosis Factor
-Tumor Necrosis Factor Receptors
-Chemokines
-CXC Chemokines
-CC Chemokines
-C Chemokines
-CX3C Chemokines
-Biological Role of Chemokines
-Chemokine Receptors
-Chemokines and Disease States



3 Cytokine Receptors and Signaling



Introduction
-Immunoglobulin Superfamily Receptors
-Class I Cytokine Receptor Family
-Class II Cytokine Receptor Family
-Tumor Necrosis Factor Receptor Family
-Chemokine Receptor Family
-Cytokine Receptor-Associated Transcription Factors
-Signal Transducers and Activators of Transcription
-Janus Kinases
-The Janus Family Tyrosine Kinases–Signal Transducers and Activators of Transcription Signaling Pathway
-The JAK–Cytokine Receptor
-Interaction Mitogen-Activated Protein Kinases
-Mitogen-Activated Protein Kinases in Immune Response
-Effects of Mitogen-Activated Protein Kinases on T Cells
-Cell Surface Signals Activate Extracellular Signal-Regulated Kinase
1/2 and Other Mitogen-Activated Protein Kinases
-Nuclear Factor-κB
-Inhibitors of Cytokine Cell Signaling
-SH2-Containing Phosphatase Proteins
-Protein Inhibitors of Activated Signal Transducers and Activators of Transcription
-Suppressors of Cytokine Signaling

4 Immunosuppressive Agents

Introduction
-Calcineurin Inhibitors
-Cyclosporine
-Tacrolimus
-Target of Rapamycin Inhibitors
-Sirolimus
-Everolimus
-Sphingosine 1-Phosphate Receptor (S1P-R) Modulators
-Fingolimod
Cytotoxic Agents
-Mycophenolate Mofetil (CellCept)
-Azathioprine
-Cyclophosphamide
Glucocorticoids
-Mechanism of Action
-Absorption, Distribution and Excretion
-Side Effects
-Clinical Uses
-Polyclonal Antibodies
-Antithymocyte Globulin
-Rho(D) Immune Globulin
-Monoclonal Antibodies
-Future Directions



5 Monoclonal Antibodies as Therapeutic Agents

Introduction
-Production of Monoclonal Antibodies
-Screening and Cloning
-Murine Antibodies as Therapeutic Agents
-Chimeric Antibodies
-Complementarity-Determining Region-Grafted Antibodies
-Therapeutic Uses of Monoclonal Antibodies
-Tissue Transplantation
-Psoriasis
-Rheumatoid Arthritis
-Thrombosis
-Treatment of Cancer


6 Allergic Disease


Introduction
-Hypersensitivity Disease
-IgE-Mediated Responses
-Regulation of IgE Synthesis
-Immediate Hypersensitivity Reaction
-Allergic Inflammation
-Receptors Associated with Allergic Disease and Asthma
-Genetic Predisposition
-The Role of T Cells in Allergic Disease and Asthma
-The Role of Signal Transducers and Activators of Transcription in Allergic Disease
-Neural Pathways in Allergic Disease and Asthma
-Role of Neuropeptides in Airway Inflammation
-Neurotrophins and Allergic Disease and Asthma
-Gene for Allergic Disease
Specific Immunotherapy
-Sublingual Immunotherapy
-Ragweed Toll-Like Receptor 9 Agonist Vaccine for Immunotherapy
-Probiotics for the Treatment of Allergic Disease



7 Tissue Transplantation

Introduction
-Tissue Typing in Transplantation
-Mechanisms of Rejection in Tissue Transplantation
-Role of Innate Immune Response in Allotransplant Rejection
-Types of Organ Rejection
-Hyperacute Rejection
-Acute Rejection
-Chronic Rejection
-Transplant Tolerance
-Procedures for Preventing Graft Rejection
-Clinical Issues in Tissue Transplantation
-Graft-Versus-Host Disease
-Clinical Transplantation
-Kidney Transplantation
-Liver Transplantation
-Pancreas Transplantation
-Heart Transplantation
-Lung Transplantation
-BoneMarrow Transplantation




8 Acquired Immune Deficiency Syndrome

Introduction
Human Immunodeficiency Virus
-Human Immunodeficiency Virus Replication
-Human Immunodeficiency Virus and Disease
-Human Immunodeficiency Virus Transmission
-Criteria for Diagnosis
-Clinical Strategies for the Treatment of AIDS
-Reverse Transcriptase Inhibitors
-Human Immunodeficiency Virus Protease Inhibitors
-Drugs Inhibiting Viral Binding
-Drugs Stimulating the Immune Response
Future Anti-Human Immunodeficiency Virus Drugs
-Under Development
-Combination Therapy for AIDS
-Vaccines for HIV Infection



9 Regulatory T Cells and Disease State

Introduction
-Types of Regulatory T Cells
-Naturally Occurring Treg Cells
-Peripheral (Adaptive) Treg Cells
-Tr1 Cells
-TH3 Cells
-Natural Killer T Cells
-Regulatory CD8+ T Cells
-Regulatory T Cells in the Mucosal System
-T-Cell Vaccination and Regulatory T Cells
-Regulatory T Cells and Antibody Production
-Mechanisms of Induction of Treg Cells
-Antigen Specificity of Regulatory T Cells and
-Mechanisms of Suppression
-Foxp3 Expression and Regulatory T-Cell Activity
-Toll-Like Receptors and Regulatory T Cells
-CTLA-4 and Regulatory T Cells
-Regulatory T Cells and Disease States
-Allergic Disease
-Autoimmune Diseases
-Infections
-Cancer
-Transplantation
-Future Direction and Conclusion


10 Gene Therapy

Introduction
Altered Genes and Diseases of Inherited Disorders Vectors for Gene Therapy
-Adenoviruses
-Adeno-Associated Virus
-Retroviruses
-Lentiviruses
-Herpes Simplex Virus-1 Vector
-Vaccinia Vectors
-Amplicon-Based Vectors
-Nonviral Gene Therapy Vectors
-RNA Interference Gene Therapy
-Gene Therapy Using RNA Aptamers
-Treatment of Diseases by Gene Therapy
-Cancer
-Cystic Fibrosis
-Vasculature
-Cardiovascular Diseases
-Human Immunodeficiency Virus
-Hematopoietic Stem Cell as a Target for Gene Therapy
-Epilepsy
-Challenges Associated with Successful Gene Therapy
-Conclusion
Index