IMMUNOPHARMACOLOGY, KHAN, M. Manzoor. 2008.

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Idioma: Inglés
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CONTENIDO


1 Overview of the Immune Response
Introduction
-Innate Immunity
-Physical Barriers
-Chemical Barriers
-Cellular Barriers
-Innate Mechanisms
-Adaptive/Acquired Immune Response
-Immunogens and Antigens
-Antibodies
-Classes of Immunoglobulins
-Cell Cooperation in Antibody Response
-Primary and Secondary Antibody Responses
-Cells Involved in the Immune Response
-Lymphoid Cells
-Antigen-Presenting Cells
-Polymorphonuclear Leukocytes
-CellularMigration
-Cell Adhesion Molecules
-Integrins
-Selectins
-Immunoglobulin Superfamily
-Cadherins
-Molecules That Recognize Antigen
-T-Cell Receptor
-T-Cell Activation, T-Cell Receptor Complex and Signal Transduction
-Pre-T-Cell Receptor
-Antigen Recognition
-Antigen–Antibody Binding
-The Structure of Antigens
-T-Cell Antigen Recognition
-Major Histocompatibility Complex
-Major Histocompatibility Complex Molecules



2 Role of Cytokines


Introduction
-Interleukin-1
-Kineret(Anakinra)
-Interleukin-2
-Interleukin-2 Receptors
-Clinical Uses of Interleukin-2
-Interleukin-4
-Interleukin-5
-Interleukin-6
-Interleukin-9
-Interleukin-10
-Interleukin-11
-Oprelvekin (Neumega)
-Interleukin-13
-Interleukin-18
-Interferons
-Type I Interferons
-Clinical Applications of Interferons
-Type II Interferons
-Colony-Stimulating Factors
-Clinical Uses of Colony-Stimulating Factors
-Tumor Necrosis Factor
-Tumor Necrosis Factor Receptors
-Chemokines
-CXC Chemokines
-CC Chemokines
-C Chemokines
-CX3C Chemokines
-Biological Role of Chemokines
-Chemokine Receptors
-Chemokines and Disease States



3 Cytokine Receptors and Signaling



Introduction
-Immunoglobulin Superfamily Receptors
-Class I Cytokine Receptor Family
-Class II Cytokine Receptor Family
-Tumor Necrosis Factor Receptor Family
-Chemokine Receptor Family
-Cytokine Receptor-Associated Transcription Factors
-Signal Transducers and Activators of Transcription
-Janus Kinases
-The Janus Family Tyrosine Kinases–Signal Transducers and Activators of Transcription Signaling Pathway
-The JAK–Cytokine Receptor
-Interaction Mitogen-Activated Protein Kinases
-Mitogen-Activated Protein Kinases in Immune Response
-Effects of Mitogen-Activated Protein Kinases on T Cells
-Cell Surface Signals Activate Extracellular Signal-Regulated Kinase
1/2 and Other Mitogen-Activated Protein Kinases
-Nuclear Factor-κB
-Inhibitors of Cytokine Cell Signaling
-SH2-Containing Phosphatase Proteins
-Protein Inhibitors of Activated Signal Transducers and Activators of Transcription
-Suppressors of Cytokine Signaling

4 Immunosuppressive Agents

Introduction
-Calcineurin Inhibitors
-Cyclosporine
-Tacrolimus
-Target of Rapamycin Inhibitors
-Sirolimus
-Everolimus
-Sphingosine 1-Phosphate Receptor (S1P-R) Modulators
-Fingolimod
Cytotoxic Agents
-Mycophenolate Mofetil (CellCept)
-Azathioprine
-Cyclophosphamide
Glucocorticoids
-Mechanism of Action
-Absorption, Distribution and Excretion
-Side Effects
-Clinical Uses
-Polyclonal Antibodies
-Antithymocyte Globulin
-Rho(D) Immune Globulin
-Monoclonal Antibodies
-Future Directions



5 Monoclonal Antibodies as Therapeutic Agents

Introduction
-Production of Monoclonal Antibodies
-Screening and Cloning
-Murine Antibodies as Therapeutic Agents
-Chimeric Antibodies
-Complementarity-Determining Region-Grafted Antibodies
-Therapeutic Uses of Monoclonal Antibodies
-Tissue Transplantation
-Psoriasis
-Rheumatoid Arthritis
-Thrombosis
-Treatment of Cancer


6 Allergic Disease


Introduction
-Hypersensitivity Disease
-IgE-Mediated Responses
-Regulation of IgE Synthesis
-Immediate Hypersensitivity Reaction
-Allergic Inflammation
-Receptors Associated with Allergic Disease and Asthma
-Genetic Predisposition
-The Role of T Cells in Allergic Disease and Asthma
-The Role of Signal Transducers and Activators of Transcription in Allergic Disease
-Neural Pathways in Allergic Disease and Asthma
-Role of Neuropeptides in Airway Inflammation
-Neurotrophins and Allergic Disease and Asthma
-Gene for Allergic Disease
Specific Immunotherapy
-Sublingual Immunotherapy
-Ragweed Toll-Like Receptor 9 Agonist Vaccine for Immunotherapy
-Probiotics for the Treatment of Allergic Disease



7 Tissue Transplantation

Introduction
-Tissue Typing in Transplantation
-Mechanisms of Rejection in Tissue Transplantation
-Role of Innate Immune Response in Allotransplant Rejection
-Types of Organ Rejection
-Hyperacute Rejection
-Acute Rejection
-Chronic Rejection
-Transplant Tolerance
-Procedures for Preventing Graft Rejection
-Clinical Issues in Tissue Transplantation
-Graft-Versus-Host Disease
-Clinical Transplantation
-Kidney Transplantation
-Liver Transplantation
-Pancreas Transplantation
-Heart Transplantation
-Lung Transplantation
-BoneMarrow Transplantation




8 Acquired Immune Deficiency Syndrome

Introduction
Human Immunodeficiency Virus
-Human Immunodeficiency Virus Replication
-Human Immunodeficiency Virus and Disease
-Human Immunodeficiency Virus Transmission
-Criteria for Diagnosis
-Clinical Strategies for the Treatment of AIDS
-Reverse Transcriptase Inhibitors
-Human Immunodeficiency Virus Protease Inhibitors
-Drugs Inhibiting Viral Binding
-Drugs Stimulating the Immune Response
Future Anti-Human Immunodeficiency Virus Drugs
-Under Development
-Combination Therapy for AIDS
-Vaccines for HIV Infection



9 Regulatory T Cells and Disease State

Introduction
-Types of Regulatory T Cells
-Naturally Occurring Treg Cells
-Peripheral (Adaptive) Treg Cells
-Tr1 Cells
-TH3 Cells
-Natural Killer T Cells
-Regulatory CD8+ T Cells
-Regulatory T Cells in the Mucosal System
-T-Cell Vaccination and Regulatory T Cells
-Regulatory T Cells and Antibody Production
-Mechanisms of Induction of Treg Cells
-Antigen Specificity of Regulatory T Cells and
-Mechanisms of Suppression
-Foxp3 Expression and Regulatory T-Cell Activity
-Toll-Like Receptors and Regulatory T Cells
-CTLA-4 and Regulatory T Cells
-Regulatory T Cells and Disease States
-Allergic Disease
-Autoimmune Diseases
-Infections
-Cancer
-Transplantation
-Future Direction and Conclusion


10 Gene Therapy

Introduction
Altered Genes and Diseases of Inherited Disorders Vectors for Gene Therapy
-Adenoviruses
-Adeno-Associated Virus
-Retroviruses
-Lentiviruses
-Herpes Simplex Virus-1 Vector
-Vaccinia Vectors
-Amplicon-Based Vectors
-Nonviral Gene Therapy Vectors
-RNA Interference Gene Therapy
-Gene Therapy Using RNA Aptamers
-Treatment of Diseases by Gene Therapy
-Cancer
-Cystic Fibrosis
-Vasculature
-Cardiovascular Diseases
-Human Immunodeficiency Virus
-Hematopoietic Stem Cell as a Target for Gene Therapy
-Epilepsy
-Challenges Associated with Successful Gene Therapy
-Conclusion
Index